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A meta-analysis of 55 studies revealed a global pooled prevalence of depressive disorders in perimenopausal women at 33.9% (95% CI: 27.8-40.0%) (25)

For example, ROS can activate nuclear factor kappa B (NF-B), a key transcription factor that regulates the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules [134]

289 In addition, neuromuscular junction dismantling and denervation occur in aged muscle, which are also key factors contributing to the onset of clinical symptoms and pathogenesis of ALS

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