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There is an accumulating body of evidence to suggest that choledocholithiasis can be managed during a single procedure by incorporating intraoperative cholangiography (IOC) with laparoscopic common bile duct exploration (LCBDE) at the time of cholecystectomy (LC with IOC LCBDE)

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These include pairing KRAS inhibitors with other targeted agents, such as EGFR or SHP2 (SH2 containing protein tyrosine phosphatase-2) inhibitors, which target pathways commonly reactivated in resistant tumors [167]