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Higher retatrutide doses (10-12 mg) produce more GI side effects and carry a higher risk of dysesthesia (tingling/numbness) without engaging the amylin pathway

A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

When a full course produces nothing noticeable, additional courses may or may not change the outcome there's no data to guide that decision

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