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In the initiation phase, a co-oxidant (such as OH-) removes a bisallylic hydrogen atom from the methylene carbon, which links the two double bonds of polyunsaturated fatty acyl moieties, and then a carbon-centered phospholipid radical (PL) is formed

Once it finishes its job, it becomes "oxidized" or spent

Pryor WA, Stone K

Our previous study [15] has shown that copper homeostasis is disrupted in the testes of copper-overloaded mice, and the expression of FDX1 is significantly upregulated with a significant increase in testicular tissue cell apoptosis rate, suggesting that cuproptosis may be involved in the death of spermatogenic cells