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A counteracting agent may be the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, an anti-ulcer peptide per-orally active (12-15) that may also affect many central disturbances (16-23), efficient in inflammatory bowel disease trials (PL 14736) (24, 25) and various wound treatment (26-28), no toxicity reported (12, 13, 24, 25)) which showed various hepatoprotective effects (29-31)

Furthermore, other post-translation modifications of keap-1 (glycosylation, phosphorylation, glutathionylation and SUMOylation) is also reported indicating that the type of modifier is critical to determine how Keap-1 is chemically modified and Nrf2 is released (Song et al., 2023)

By inhibiting this enzyme, 5-Amino helps reduce the size of fat cells and boosts NAD+ levels, an essential molecule for mitochondrial energy production