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Cancer-associated cachexia (CAC) was blocked in PNPLA2-deficient mice and to a lesser extent in HSL-deficient mice, demonstrating that lipolysis is essential for CAC (214)

Marrs et al., 1984) LD 50 oral mouse: 946 mg/kg (Marrs et al., 1984) LD 50 intravenous rat: 57 mg/kg (Kiese et al., 1975) LD 50 oral rat: 689-780 mg/kg (Marrs et al., 1984) LD 50 intravenous dog: 26 mg/kg (Weger, 1975) In all five studies, the cause of death was inadequate oxygen transport by the blood to the tissues because 85% of the haemoglobin had been converted to methaemoglobin

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Headache: Occasional, usually transient during the first week