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Description

System xc - cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

Anzali BC, Goli R, Torabzadeh A, Kiani A, Rasouli M, Balaneji SM

Notably, we found that phosphorylation status of KRAS impacts ligand engagement via disruption of the nucleotide exchange factor SOS1, altering binding of clinically approved inhibitors to multiple oncogenic mutants