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In addition, metabolomics analysis showed an increased levels of glutamate, glutamine, glycine, aspartate and DMG in G93A-SOD1 compared to control cells (Fig

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The plasma concentrationtime profiles showed a rapid one-peak course until T max , followed by a multiphasic decrease, which probably reflected a distribution and elimination phase

We further speculated that loss of the extracellular GSH pool in gsh2 mutants could change the external environment and consequently affect extracellular redox homeostasis