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However, the optimal dosage, administration route and long-term safety of NADPH precursors remain unvalidated in large animal models, and the crosstalk of NADPH metabolism, iron homeostasis and retinal inflammation is poorly understood, limiting clinical translation of NADPH-targeted therapies and requiring further investigation

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The data for the three movement parameters were combined across treatments and ages to determine the relationship between the estimated parameters, all were found to be positively correlated ( Supplemental Figure S14 )

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