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10.1016/j.jare.2025.03.049 51 YangH.LvD.QuS.XuH.LiS.WangZ.et al (2024)

Future research should therefore focus on the development of stable formulations, reliable preclinical models that integrate both analgesic and regenerative endpoints, and well-designed clinical trials to validate efficacy and safety in human patients

A recent study reported high autophagy protein expression (AMBRA 1 and Beclin 1) in neural tissue enriched in NSCs, such as the sub-ventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus (Yazdankhah et al., in vivo and a deficiency in neuronal differentiation (Wang et al., 2013)