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Improved cellular delivery of antisense oligonucleotide for miRNA-21 imaging in vivo using cell-penetrating peptide-based nanoprobes

In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29

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However there has no report about increase the GSH production by modification of the precursor pathway