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Lower dose semaglutide (0.1, 0.2 and 0.4 mg) improved non-alcoholic steatohepatitis (NASH) in another trial (mean age 55.9 years, but the inclusion of older adults up to 75 years)

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Free Radic Biol Med 27:11141121 Martin C, Dubouchaud H, Mosoni L, Chardigny JM, Oudot A, Fontaine E, Vergely C, Keriel C, Rochette L, Leverve X, Demaison L (2007) Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius

As research progresses, an increasing number of human diseases have been linked to widespread mitochondrial defects