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For siRNA-mediated knockdown, siRNA SMARTpools for human ERK1/2, CPT1A, and scramble control were purchased from Dharmacon (Lafayette, CO)

25 At the indicated time intervals, blood APAP levels was significantly higher in IL-1ra KO mice than in WT mice (Figure 1d)

For C MAX and AUC, the simulated exposures in infants were also compared to the well-tolerated threshold in mothers receiving a single low dose of primaquine (0.25 mg base/kg)

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