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The PGPRs affect plant metabolisms by acting on several mechanisms, including the production of exopolysaccharides, plant hormones, and carotenoids, nitrogen fixation, siderophore, amplified light and CO 2 fixation rates, improved root and shoot system in response to drought stress, They also help in the development of induced systemic tolerance (IST) (Langeroodi et al

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(2) Synthesis of the isoprenoid tail: The isoprenoid tail of CoQ is synthesized through the cytosolic mevalonate pathway, which produces key precursors such as isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) 28,31

Moreover, TMAO increased the expression and activity of tissue factor (TF) via activation of the NF-B signaling pathway in primary human coronary artery endothelial cells (HCAECs), thereby promoting atherothrombosis (Cheng et al., 2019)