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In the context of type 2 diabetes, the connection between low B 1 and B 6 levels and reduced homocysteine is noted, emphasizing the relevance of B-vitamin deficiencies in diabetic nerve complications

Yet, much of the mechanistic findings rely on supraphysiological Mn doses in vitro and need confirmation at physiologically relevant Mn concentrations in vivo

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As uric acid builds up, it can accumulate in the joints, causing gout pain, or back up into the kidneys and contribute to kidney stones