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You might notice that even mild stimuli, such as brushing your teeth or a gentle breeze, can provoke intense pain episodes

This seasonal pattern relates to several factors: Humidity changes: The transition from dry winter air to humid spring conditions Temperature fluctuations: Rapid weather changes stress the skin Allergen exposure: Spring pollens may trigger immune responses Sunlight variations: Changes in UV exposure affect skin biology Interestingly, while summer's heat and humidity might seem like they would worsen SD, the increased UV exposure actually has an anti-inflammatory effect that can improve symptoms

tirzepatide additionally carries a labeled boxed warning, while CagriSema has no label yet

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