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Neuron 2012

Disease in females is possible through mutations in both X chromosomes and, in older women, age-related skewing of X-chromosome inactivation in erythroid precursors

Calibration of prediction models was evaluated by joint hypothesis testing of the intercept (null=0) and slope (null=1) at 6, 12, 24, and 36 mo, with p 70 years of age

Acts as a macrophage DAMP molecule like MSU crystals to promote hyperuricemia and its complications ( via NLRP3 inflammasomes in macrophages ( UA activates phagocytosis by macrophages MSU crystals promote phagocytosis by macrophages