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When acting alone, EPA and DHA are highly effective antioxidants, but they can be further augmented in synergism with marine carotenoids like astaxanthin, stimulating the transcription of NAD(P)H quinone dehydrogenase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione S-transferase Mu 2 (GSTM2), essential in controlling oxidative reactions [41]

This integrated approach reflects the philosophy behind formulations developed by iThrive Essentials, which emphasize bioavailability, purity, and synergistic nutrient combinations rather than isolated ingredients

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