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Potential roles of selenium metabolism in OA The protective effect of selenium in OA has been explored in a large number of epidemiological and genetic studies (Table 1)

Briefly, 200 l of the working reagent was added to 25 l of sample (properly diluted in distilled water), shaken, and subsequently incubated at 37C for 30 min

doi: 10.1002/art.20626 85 ChoHJKangJHParkKKChoeJYParkYYMoonYSet al

Similar to the role of ferroptosis as the initial driver of cell death folic acid-induced AKI, discussed below, ferroptosis is the main driver, rather than apoptosis and necroptosis, of steatohepatitis in a mice fed a choline-deficient, methionine-supplemented diet.42 There are several in vivo links between ferroptosis-related events and human or experimental neurological disorders (e.g