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Animal model studies consistently show that pharmacological inhibition of ferroptosis or genetic upregulation of GPX4 expression leads to significantly reduced MMP and ADAMTS expression in cartilage tissue, accompanied by marked improvement in cartilage structural integrity (Dong et al., 2025

Methods Human neutrophil isolation Human neutrophils were isolated from normal donor blood by Ficoll density centrifugation, as previously described 67

The clinical features of an acute hyperammonaemic episode depend on the age of the patient and the cause of the elevation in plasma ammonia levels

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