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In particular, the constant high urinary background levels of NAcLys-BDA in the range of NAcLys-[ 13 C 4 ]-BDA concentrations observed in response to the highest dose of [ 13 C 4 ]-furan (1 mg/kg bw) and estimated to correspond to a furan intake of 1.6 and 2.1 mg/kg bw in male and female rats, respectively, provide clear evidence for a significant but yet unexplored source of furan or its metabolites

Taken together, these studies underscore the potential of gut-targeted therapies in managing the multi-systemic symptoms of CFS/ME

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