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Humphreys, B

Within the myocardium, mitochondrial ROS spikesparticularly during ischemiareperfusion and reverse electron transporttrigger mPTP opening, Ca mishandling and cell death programs (Drummond and Sobey 2014

Gut barrier integrity is another factor: MS patients in remission versus flare have been noted to have differences in fecal microbiota that may impact gut permeability