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Based on the positive results from three Phase III studies, in 2012 FDA approved topiramate/phentermine extended-release as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in eligible adults

For specifically IgG2, this difference in transcytosis is not mirrored by a shorter plasma half-life than IgG1, which highlights the complex nuances of FcRn-mediated transport [338]

Samples were then evaporated to dryness in Speed vac and resuspended in 500 l Buffer A (95% H 2 O, 5% CH 3 CN, 0.1% FA) with sonication and loaded on HPLC for offline high pH fractionation following conditions adapted from previous work 57

A species/strain comparison of hepatic natural lymphocytotoxic activities in rats and mice