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Activation of the polyol pathway depletes NADPH, leading to AGEs binding to their receptors on cell surfaces, resulting in oxidative stress, ROS generation, and activation of PKC and ERK1/2 signaling pathways, ultimately promoting TGF- secretion, mesangial cell proliferation, and ECM synthesis, culminating in renal fibrosis [73]

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Glutathione Side Effects While glutathione is generally considered safe, potential side effects may include mild symptoms such as bloating, allergic reactions like rashes or itching, and, in rare cases, breathing problems if not administered properly

Paeoniflorin Protects against Dextran Sulfate Sodium (DSS)-induced Colitis in Mice through Inhibition of Inflammation and Eosinophil Infiltration