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What if there was something that could have a much more dramatic effect on aging at the cellular level, that takes less time and effort, and in many cases is more cost-effective

TM2, in particular, adopts a conformation in the orforglipron-bound structure that would be difficult to predict computationally, highlighting the receptor's conformational flexibility and the inherent limitations of structure-based drug design for class B GPCRs

It also stimulates the secretion of growth hormone without increasing cortisol or ghrelin levels