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Arsenic exposure has been shown to significantly elevate intracellular ROS levels, and an excess of ROS can cause oxidative damage to DNA, resulting in modifications to DNA bases and double-strand breaks

However, studies of the IGF system in cancer metabolism are still insufficient, not only the uptake and utilization of glucose, but also the mechanism of changes in lipid and amino acid metabolism still need to be explored

AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases

This may raise the possibility that pain, an early symptom of COVID-19, could be diminished by the SARS-CoV-2 S-protein interaction with NRP1 323