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FIGURE 4 Risk of bias The risk of bias and the quality of the observational non-randomized studies were analyzed in the meta-analysis through Cochranes Risk Of Bias tool in Non-randomized Studiesof Exposure (ROBINS-E)

By sequencing the transcriptomes of a large cohort of mice subjected to various treatments and integrating the dataset with gene expression profiles from multiple strains, species, and intervention models with corresponding survival data, we identified multi-species multi-tissue signatures of lifespan and mortality