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Ferroptosis in musculoskeletal diseases Musculoskeletal diseases, such as osteoarthritis, osteoporosis, sarcopenia, and amyotrophic lateral sclerosis, seriously impair patients quality of life and place a substantial strain on global public health resources

Superoxide anion (O 2 - ), hydroxyl (OH ), alkoxy radicals (RO ), peroxyl radicals (ROO ), nitric oxide radical (NO ), nitrogen dioxide (NO 2 ), and carbonate radical (CO 3 - ) are the few examples of radical ROS whereas non-radical ROS include singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and peroxynitrite (ONOO - ) species which can readily trigger free radical reactions in organisms [23, 24]