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8.1 Gene modification of MSCs Genetic modification of mesenchymal stem cells (MSCs) using viral or non-viral vectors can induce the overexpression of functional proteins and soluble factors, thereby enhancing stemness, differentiation, migration and homing capabilities, immunomodulation, and other repair-related functions ( in vitro and in vivo ), and improving their resistance to harsh microenvironments and apoptosis

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Some have proposed that ammonia is converted to glutamine, which causes cerebral edema either directly by its osmotic effect 37,38 or indirectly by decreasing other osmolytes, thereby promoting water retention