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doi: 10.1038/s41594-017-0011-7 68 RioboNAManningDR

This finding underscores MOTS-cs natural role: when you work out, mitochondria release more MOTS-c, which then helps ramp up energy production and protect cells almost like an internal workout supplement

Given its significant role in brain health and neurotransmitter signalling, low levels of B12 can affect mood regulation, contributing to feelings of sadness or lack of motivation