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IV formulations can be effective, however the costs can be significant ($900 per session), factor in 4 sessions, for temporary results that typically last 3-8 weeks

J Res Pharm Pract

MSH biosynthesis enzymes in Streptomycetes are redox-controlled under diamide stress by the disulfide stress specific R ECF sigma factor/RsrA anti sigma factor system (Kim et al., 2012)