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They can also block receptors on cancer cells, for example, growth factors

Song K, Duan Q, Ren J, Yi J, Yu H, Che H et al (2022) Targeted metabolomics combined with network pharmacology to reveal the protective role of luteolin in pulmonary arterial hypertension

However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]