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Elective surgery has also long been used as a paradigm of the stress response in humans (188-190): the magnitude of cortisol rise correlates positively with the severity of surgery (191)

The 2005 digestive enzyme study offers insights into gastrointestinal effects and the normalization pattern that appears characteristic of bioregulator activity

Preservation of Mitochondrial DNA (mtDNA):mtDNA lacks protective histones and is located near the ROS-generating inner mitochondrial membrane, making it highly susceptible to oxidative damage

In macrophages and several other cell types, inflammatory mediators induce the transcriptional activation of the iNOS gene, resulting in accumulation of iNOS and increased synthesis of NO