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The last observed value can either replace a missing weight assessment for a trial participant lost to follow up or replace weight assessments that were taken after discontinuation of the active treatment or placebo, if the participant continued to have weight assessments taken at pre-determined times while off treatment

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Many blood cancers, such as aggressive B- and T-cell lymphomas, as well as acute lymphoblastic and myeloid leukemia, still exhibit poor outcomes with rapid progression after first-line treatments