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However, in C26 tumor-bearing mice, neither inhibition nor activation of autophagy rescued the muscle function, and both treatments worsened the outcome [77]

Interestingly, adult mice with modest isolated elevations in GH and IGF-1 levels have greater lean mass, improved lipid oxidation and glucose clearance 38 , while specific, temporal reductions in GH and IGF-1 in adults have been linked to deleterious metabolic effects, including impaired hepatic insulin action 38 , and reduced -cell mass and function 39

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Key differences: exogenous GH suppresses endogenous GH production through negative feedback (IGF-1 hypothalamus), while ipamorelin does not