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Under pathological conditions, high Ca 2+ concentration can promote the opening of mitochondrial permeability transition pore (MPTP) and induce apoptotic death (35, 36)

and Han, J.M

doi: 10.1111/j.1399-6576.1996.tb04493.x

Evidence from clinical trials suggests that specific regimensparticularly time-restricted eating and ADFlead to significant decreases in fasting glucose, glycated hemoglobin (HbA1c), and insulin resistance [13]