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Pediatr Res 93(7):18191827 Hassell KJ, Ezzati M, Alonso-Alconada D, Hausenloy DJ, Robertson NJ (2015) New horizons for newborn brain protection: enhancing endogenous neuroprotection

The doses were chosen in order to monitor autoprotection across a range of sub-toxic, threshold toxic and overtly toxic doses of APAP, to ensure that the drug exposure is relevant to what may occur in humans