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ROS can also trigger changes in epigenetics in the promoter area of E-cadherin and other tumor suppressor genes leading to tumor development and metastasis

In TNBC cells with decreased GLS expression, increased levels of carnitine palmitoyltransferase 1A/B (CPT1A/B), CPT2, and carnitine O-acetyltransferase (CRAT) may be potential predictive markers for CB-839 resistance