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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Kahn RS, Keefe RS

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Obstruction of GSH synthesis affects the lipid membrane repair ability of GPX4, increases the rate of toxic lipid free radical and ROS accumulation, and promotes lipid peroxidation, resulting in ferroptosis [1, 2]