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Patients usually present with chronic pain, decreased range of motion, and accompanying weakness

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Ameliorative effect of curcumin on lead-induced hematological and hepatorenal toxicity in a rat model

In vitro studies have shown that certain flavonoids, at high concentrations, can inhibit the growth of probiotic bacteria such as Lactobacillus app., while promoting the proliferation of opportunistic pathogens and inducing the accumulation of harmful metabolites, including H 2 S and NH 3 (Pan et al., 2023), which may adversely affect gut microbial homeostasis under specific conditions