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Conversely, excessive ROS oxidize and damage cellular components, leading to cellular death (Luo et al., 2020

As there is no miraculous cure or universally effective treatment for keratosis pilaris, it is important to proceed with caution

Given that core metabolic processes, including nucleotide synthesis, glycolysis, and redox defense, are fundamentally shared with normal proliferative tissues, broad-spectrum metabolic inhibition often lacks true selectivity and precipitates dose-limiting systemic toxicities [43]

These infections not only diminish quality of life but also impose a substantial socio-economic burden, with billions of dollars spent annually on treatment and disability support