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Paddock MN, Bauman AT, Higdon R, Kolker E, Takeda S, Scharenberg AM

Using a mouse model harboring the kidney specific inactivation of TSC1 that developed progressive renal lesions that eventually resulted in cortical renal papillary carcinoma, it was shown that TSC1 inactivation results in the accumulation of fumarate due to mTOR-dependent downregulation of the FH