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Graphical abstract Access this article Similar content being viewed by others Abbreviations GI: Gastrointestinal GERD: Gastroesophageal reflux disease WHO: World health organization IBD: Inflammatory bowel disease FGIDs: Functional GI disorders IBS: Irritable bowel syndrome AF: Anal fissures HD: Hemorrhoidal disease DNA: Deoxyribonucleic acid ERK: Extracellular signal-regulated kinase TNF-: Tumor necrosis factor- NF-B: Nuclear factor B H 2 O 2 : Hydrogen peroxide SOD: Superoxide dismutase GSH: Glutathione ROS: Reactive oxygen species ROI: Reactive oxygen intermediates UC: Ulcerative colitis UV: Ultraviolet radiations XO: Xanthine oxidase NO: Nitric oxide LDH: Lactate dehydrogenase GPx: Glutathione peroxidase CAT: Catalase MnSOD: Mn superoxide dismutase ALP: Alkaline phosphatase ACP: Acid phosphatase MeSH: Medical subject heading MPO: Myeloperoxidase MAPK: Mitogen-activated protein kinase PUD: Peptic ulcer diseases KEAP1: Kelch-like ECH- associated protein 1 TBA: Thiobarbituric acid DALYs: Disability-adjusted life years NrF 2: Nuclear factor erythroid related factor 2 NSAIDS: Non-steroidal anti-inflammatory drug NADPH: Nicotinamide adenine dinucleotide phosphate TBARS: Thiobarbituric acid reactive substances SGOT: Serum glutamic oxaloacetic transaminase SGPT: Serum glutamate pyruvate transaminase PRISMA: Preferred reporting items for systematic reviews and meta-analysis TLESR: Transient lower esophageal sphincter relaxations References Abbas MW, Shamshad T, Ashraf MA, Javaid R (2016) Jaundice: a basic review