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Observational studies are prone to residual confounding because they do not involve random assignment of participants to treatment and control group

While PCSK9 inhibitors have demonstrated efficacy in lowering serum Lp(a) levels and mitigating adverse events associated with PAD, there is a dearth of research on the management of PAD individuals who have increased Lp(a) and insufficient evidence for Lp(a)-specific therapies at this time