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Ligand binding to subsite C influences specificity of NE uptake inhibition The structures of SNRIs duloxetine, milnacipran, and tramadol in complex with the dDAT show a progressively smaller aromatic moiety that interacts with the subsite B and C in the primary binding pocket of dDAT

This moderate pressor effect is likely due to its nitric oxide scavenging effects 2 and this drug is sometimes used as an offlabel treatment for vasoplegic syndrome 3