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[18] [19] APP is cleaved into smaller fragments by enzymes such as gamma secretase and beta secretase

Additionally, the analgesic effect of methadone is shorter than the pharmacologic half-life, leading to potential additive respiratory depression if the medication is dosed solely based on pain

Chan School of Public Health, Harvard University, Boston, MA, USA Pranil Man Singh Pradhan Askok and Rita Patel Institute of Physiotherapy, Charotar University of Science and Technology, Anand, India V