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In all conformations, the C-terminal arm forms variable hydrogen bonds to the guiding bar residues (Trp407 hTrxR1 , Asn418 hTrxR1 , Asn419 hTrxR1 )

Mechanically, artesunate upregulated the expression of autophagy-associated proteins and inhibited the expression of FTH1 and NCOA4, indicating that ferritinophagy-mediated ferroptosis in HSCs is crucial in the antifibrotic therapy of artesunate (Kong et al., 2019)

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Although it is difficult to determine specific solubilities without either finding them by experiment or referring to a table of solubilities, we do have guidelines that allow us to predict relative solubilities