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Shellac-based and oil-based primers are the strongest options because they: Seal smoke residue so it cant escape Prevent brown or yellow nicotine stains from bleeding through Create a stable base for the topcoat A widely used example is Zinsser B-I-N, which is known for its strong odour-sealing performance

Nicotine is known to affect the immune response in inammatory conditions by inducing the production of adrenal steroids through the hypothalamuspituitaryadrenal axis and reducing the production of TNF- and interleukins 1 and 6 through its direct effect on macrophages

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