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Many clinical and preclinical studies have proven the beneficial effects of berberine in diabetes mellitus, mainly due to its ability to enhance insulin expression and potential antioxidant effects, as well as improving spatial reminiscence impairment in diabetic rats (116)

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Experimental studies on murine models indicate that DSIP may enhance the inhibitory actions of GABA, thereby reducing neural excitability and facilitating the onset of sleep

Of these must-haves, only four are fat-soluble, meaning the body can store them within the fat cells when taken and/or consumed in excess