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Another typical feature of PCOS is chronic anovulation and the standard approach for the treatment of women with anovulation infertility consists of administration of clomiphene citrate to induce ovulation, however, some women fail to ovulate despite taking increasing doses of clomiphene citrate and, therefore, defined as clomiphene citrate-resistant PCOS

Other targeted ALS pathways include neurotrophic factors, oxidative stress, neuromuscular junction and axonal integrity, mitochondrial function and energy expenditure, RNA metabolism, and the gutbrain axis (Fig

Liu Y, Lee JM, Lee C

The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5alpha-reductase-2 gene mutation